The Center for Translational Research in Aging and Longevity

The research group of the Center for Translational Research in Aging and Longevity (CTRAL) at the Donald W. Reynolds Institute on Aging, UAMS consists of 2 groups.  The group of Dr. Robert Wolfe and Dr. Arny Ferrando that moved from the University of Texas in Galveston (UTMB), and Dr. Elisabet Borsheim and her group of researchers.  Dr. Wolfe’s group has extensive years of experience in research on clinical nutritional and metabolism and research with stable isotopes.  Our goal is not only to just perform animal and human (basic and clinical) research, but also to translate results obtained from research into practice.  Dr. Borsheim recently joined UAMS and has appointments at Arkansas Children’s Hospital and the Department of Geriatrics, Donald W. Reynolds Institute on Aging.  Her areas of interest are closely aligned with those of Dr. Wolfe and Dr. Ferrando and include nutrition and muscle metabolism.  Dr. Borsheim is also one of the co-directors of the Analytical Core on the Arkansas Claude D. Pepper grant.

Dr. Il-Young Kim, an Assistant Professor, has been with the Center for several years now and his work deals with many different aspects of aging, such as protein metabolism, compromised blood flow, and nutritional supplementation.

Dr. Bryce Marquis, an Assistant Professor, works with metabolomic changes with aging, in particular those dealing with skeletal and cardiac muscle. 

What is Translational Research?

Translational research is an approach to research that seeks to produce more meaningful, applicable results that directly benefit human health.  This approach emphasizes removing barriers to multidisciplinary collaboration among laboratory and clinical researchers. It also incorporates the desires of the general public, with communities being engaged to determine their needs for health innovation.  The goal is to move basic science discoveries more quickly and efficiently into practice.  This concept is often summarized by the phrases “bench-to-bedside” and “bedside-to-community” research.  Translational research also encompasses efforts to identify and support the adoption of best medical and health practices.  At the University of Arkansas for Medical Sciences (UAMS) translational research provides numerous targeted resources to address barriers that can curb productivity and the swift translation of research into new health care advances.

TRI Graphic

The National Center for Advancing Translational Sciences (NCATS), which supports the work of TRI, studies translation on a system-wide level as a scientific and operational problem. The NCATS website states that:

  • Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes.
  • Translational science is the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process.