il-young-kim-phd

 

 

 

 

 

 

 

IL-YOUNG KIM, Ph.D.
Assistant Professor, Department of Geriatrics
Center for Translational Research in Aging & Longevity
The University of Arkansas for Medical Sciences Donald W. Reynolds Institute on Aging
4301 West Markham Street, Mailbox 806
Little Rock, AR 72205

Office  501-526-5707
Cell  512-971-0235
Fax  501-526-5710

iykim@uams.edu

RESEARCH INTERESTS

My current research interest is on the in-depth understanding of metabolic alterations in relations to various aspects of human pathophysiology (i.e., disease conditions, particularly, age-related metabolic dysregulation) and normal physiology in combination with nutritional supplement, exercise, etc. by using stable isotope tracer methodology with gas chromatography and mass spectrometry (GC/MS) and liquid chromatograph and mass spectrometry (LC/MS).

CONTRIBUTION TO SCIENCE

My current work at UAMS has been primarily focused on nutritional approach to improve metabolic health in older adults using stable isotope tracer technologies. Primary focus of my research has been on determining anabolic responses to protein intake in mixed meals in older adults. Older adults experience a progressive loss of muscle mass and strength, called sarcopenia, which is associated with many healthy problems of great socioeconomic impact, including increased risks of insulin resistance and diabetes, falls, fracture, and mortality, as well as negatively impacting quality of life. We have found that a greater net protein gain at whole-body level was achieved with ~2 x RDA (Recommended Dietary Allowance) as compared to 1RDA (0.8g/kg bw/day), primarily through increases in protein synthesis both at whole body and muscle levels. The findings provide a basis for dietary recommendations for optimal protein intake in the elderly population. One of the other research focuses has been on the effect of acute lysine supplementation on insulin sensitivity and glucose metabolism in older adults. Second, my research has also focused on hepatic and peripheral insulin sensitivity as determined directly by determining glucose kinetics in response to acute supplementation of nutrient or following a chronic intake of protein in mixed meals. In terms of acute effect of nutrient, we investigated the effect of acute lysine supplementation on insulin sensitivity and glucose kinetics. Contrary to the previous findings in healthy young adults, we found in older adults that acute lysine supplementation did not improve whole body insulin sensitivity and glucose kinetics. The findings demonstrated differential effects of age in whole-body response in glucose kinetics and insulin sensitivity for a given lysine supplementation. Lastly, we have investigated rate of nitric oxide synthesis, a potent vasodilator, and peripheral vascular function (forearm blood flow) in response to acute ingestion of citrulline. We found that nitric oxide synthesis in the fasted state was ~70% lower in older subjects compared with young subjects. However, we found 3g of citruline ingestion stimulated nitric oxide synthesis by ~ 10 fold without corresponding improvement of peripheral vascular function, indicating other than nitric oxide synthesis may also play a role in regulation of peripheral blood flow.

  • Kim I-Y, Schutzler SE, Schrader A, Spencer H, Kortebein P, Deutz NE, Kortebein P, Wolfe RR, and Ferrando AA. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults. Am J Physiol Endo and Metab. 308(1):E21-8, 2015. PMCID: PMC 4280213
  • Kim I-Y, Schutzler SE, Schrader A, Spencer H, Gohar A, Ferrando AA and Wolfe RR, The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. American Journal of Physiology, Endocrinology and Metabolism, 2016. PMID: 26530155
  • Kim I-Y, Williams RH, Schutzler SE, Lasley CL, Bodenner DL, Wolfe RR and Coker RH. Acute lysine supplementation does not improve hepatic or peripheral insulin sensitivity in older, overweight individuals. Nutr Metab. 11(1):49, 2014. PMCID: PMC4198625
  • Kim I-Y, Schutzler SE, Schrader A, Spencer H, Gohar A, Deutz NE and Wolfe Acute ingestion of citrulline stimulates nitric oxide synthesis in young and older subjects with heart failure, American Journal of Physiology, Endocrinology and Metabolism 2015. PMID: 26442881
  • Baum JI, Kim I-Y, and Wolfe RR, Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients 2016. 8(6), 359; doi:10.3390/nu8060359
  • Wolfe RR, Rutherfurd SM, Kim I-Y and Moughan Protein quality as determined by the digestible indispensable amino acid score (DIAAS): Evaluation of factors underlying the calculation, Nutrition Reviews 2016. (In Press)

EDUCATION AND PROFESSIONAL POSITIONS

2011                                        Ph.D. in Exercise Physiology and Metabolism, the University of Texas at Austin

Jun 2012–Dec 2012                Post doc, Center for Translational Research in Aging & Longevity, Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR

Jan 2013–Aug 2015                Faculty Instructor, Center for Translational Research in Aging & Longevity, Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR

Sep 2015–Present                   Assistant Professor, Center for Translational Research in Aging & Longevity, Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR

PROFESSIONAL SOCIETIES AND ORGANIZATIONS:

Present, Member, American Physiological Society Present, Member, American College of Sports Medicine Present, Member, American Society for Nutrition

Present, Commissioner, Committee of Exercise Therapy, Korean Society for the Study of Obesity

JOURNAL REVIEWER:

Present, International Journal of Sports Medicine Present, The Physician and Sportsmedicine

Present, Applied Physiology, Nutrition and Metabolism
Present, Journal of Endocrinology

HONORS AND AWARDS

2015 Feb         Best Article of the Month of American Physiology Society (Feb, 2015), the American Physiology Society: Kim I-Y, Schutzler SE, Schrader AM, Spencer HJ, Kortebein P, Deutz NE, Wolfe RR, and Ferrando AA. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults, Am J Physiol Endo and Metab, 2014. PMID: 25352437.

2016 Jan          The review paper: “Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research” (Kim IY, SH Suh, I-K Lee, and RR Wolfe) has been featured in a Research Summary in the Journal Experimental & Molecular Medicine Website (http://www.nature.com/emm/latest.html) on Jan 16th 2015.

2016 April        The review paper: “Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research” (Kim IY, SH Suh, I-K Lee, and RR Wolfe) has been featured in Korean Society for Biochemistry and Molecular Biology (KSBMB) Webzine (http://new.ksbmb.or.kr).

2016 April        The recipient of the 2016 New Investigator Award, The American Physiological Society Endocrinology & Metabolism Section, American Physiological Society.

PUBLICATIONS

  1. Trombold JR, Christmas KM, Machin DR, Kim I-Y and Coyle EF. Acute high intensity endurance exercise is more effective than moderate-intensity exercise for attenuation of postprandial triglyceride elevation. J Appl Physiol. 114: 792-800, 2013. PMID: 23372145
  2. Kim I-Y, Park S, Trombold JR and Coyle EF. Effects of moderate- and intermittent low-intensity exercise on postprandial Med Sci Sports Exerc. 46: 1882-1890, 2014. PMID: 24576868
  3. Trombold JR, Christmas KM, Machin DR, Van Pelt D, Chou T-H, Kim I-Y and Coyle Post-exercise macronutrient intake and subsequent postprandial triglyceride metabolism. Med Sci Sports Exerc. 2014. PMID: 23372145
  4. Kim I-Y, Williams RH, Schutzler SE, Lasley CL, Bodenner DL, Wolfe RR and Coker Acute lysine supplementation does not improve hepatic or peripheral insulin sensitivity in older, overweight individuals. Nutrition and Metabolism. 2014. PMID: 25324894
  5. Kim I-Y, Schutzler SE, Schrader A, Spencer H, Kortebein P, Deutz NE, Kortebein P, Wolfe RR, and Ferrando AA. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults, Am J Physiol Endo and Metab, PMID: 25352437
  6. Kim I-Y, Schutzler SE, Schrader A, Spencer H, Gohar A, Deutz NE and Wolfe Acute ingestion of citrulline stimulates nitric oxide synthesis in young and older subjects with heart failure, American Journal of Physiology, Endocrinology and Metabolism 2015. PMID: 26442881
  7. Kim I-Y, Schutzler SE, Schrader A, Spencer H, Gohar A, Ferrando AA and Wolfe RR, The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. American Journal of Physiology, Endocrinology and Metabolism, 2016. PMID: 26530155
  8. Kim I-Y, Suh S-H, Lee I-K and Wolfe, RR, Applications of Stable, Nonradioactive Isotope Tracers in In vivo Human Metabolic Experimental and Molecular Medicine 2016.
  9. Baum JI, Kim I-Y, and Wolfe RR, Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients 2016. 8(6), 359; doi:10.3390/nu8060359
  10. Wolfe RR, Rutherfurd SM, Kim I-Y and Moughan Protein quality as determined by the digestible indispensable amino acid score (DIAAS): Evaluation of factors underlying the calculation, Nutrition Reviews 2016. (In Press)

MANUSCRIPT IN REVIEW/REVISION

  1. Kim I-Y, Deutz NEP, and Wolfe Is There a Maximal Anabolic Response to Dietary Protein? Am J Clin Nutr 2016
  2. Wolfe RR, Cifelli AM, Kostas G, and Kim I-Y. Optimizing Protein Intake: Interpretation and Application of the Recommended Dietary Allowance versus the Acceptable Macronutrient Distribution Range. Advances in Nutrition 2016
  3. Kim I-Y, Schutzler SE, Gohar A, Wolfe RR and Ferrando AA. Distribution pattern of dietary protein intake does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults, Clinical Nutrition, 2016
  4. Kim I-Y, Park S, Chou T-H, Trombold JR and Coyle Several Days of Prolonged Sitting Abolish the Postprandial Plasma Triglyceride Lowering Effect of Acute Exercise, Regardless of Energy Balance, American Journal of Physiology Endocrinology and Metabolism, 2016